Publications
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Journal Articles
(*Equal Contribution / #Corresponding Author)
Last update: 17th Nov 2025
2025
102. Breaking the Mechanical Compass: Disrupting Durotaxis to Halt Fibrosis and Metastasis
Chitty JL*, Parker AL*, Cox TR#
Cancer Research (2025) [doi: 10.1158/0008-5472.CAN-25-4947]
PubMed | HTML
101. Brillouin microscopy in cancer research: a review
Falkner N, Duman MN, Zabolizadeh Z, Mahmodi H, Shi C, Zhang J, Cox TR, Kabakova I
Journal of Biomedial Optics (2025) [doi: 10.1117/1.JBO.30.12.124509]
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100. Incorporation of optical profilometry volume correction in quantitative elemental bioimaging workflows
Bordin DM, Lockwood T, Westerhausen M, McCauley JI, Jeibmann A Chitty JL Cox TR, Doble PA
Talanta (2025) [doi: 10.1016/j.talanta.2025.128923]
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99. Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Joukhdar H, Lee SS, Cox TR, Choi YS, Wise SG, Young JL, Yeo GC, Lim KS
Advanced Materials (2025) [doi: 10.1002/adma.202512523]
PubMed | HTML (Open Access) | PDF
98. Imaging Copper Levels during Life in the Brain and beyond Using a Fluorescent Copper Sensor with Multimodal Capacity
Adair LD, Trist BG, Graziotto ME, Hawtrey TJ, Rowlands BD, Rosolen SA, Cottom V, Kuligowski M, Chitty JL, Mok ETY, Cox TR, Gotsbacher MP, Double KL, New EJ
ACS Chemical & Biomedical Imaging (2025) [doi: 10.1021/cbmi.5c00024]
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97. The extracellular matrix in cancer: from understanding to targeting
Chitty JL# & Cox TR#
Trends in Cancer (2025) [doi: 10.1016/j.trecan.2025.05.003]
PubMed | HTML (Open Access) | PDF
96. Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis
Chambers CR, Watakul S, Schofield P, Howell AE, Zhu J, Tran AMH, Kuepper N, Reed DA, Murphy KJ, Channon LM, Pereira BA, Tyma VM, Lee V, Trpceski M, Henry J, Melenec P, Abdulkhalek L, Nobis M, Metcalf XL, Ritchie S, Cadell A, Stoehr J, Magenau A, Chacon-Fajardo D, Chitty JL, O’Connell S, Zaratzian A, Tayao M, Da Silva A, Lyons RJ, Goldstein L, Dale A, Rookyard A, Connolly A, Crossett B, Tran YTH, Kaltzis P, Vennin C, Dinevska M, Australian Pancreatic Cancer Genome Initiative (APGI), Australian Pancreatic Cancer Matrix Atlas (APMA), Croucher DR, Samra J, Mittal A, Weatheritt RJ, Philp A, Del Monte-Nieto G, Zhang L, Enriquez RF, Cox TR, Shi YCC, Pinese M, Waddell N, Sim HW, Chtanova T, Wang Y, Joshua AJ, Chantrill L, Evans TRJ, Gill AJ, Morton JP, Pajic M, Christ D, Hertzog H, Timpson P, Herrmann D
Science Advances (2025) [doi: 10.1126/sciadv.adq4416]
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95. Advances in extracellular matrix-associated diagnostics and therapeutics
Karsdal M, Cox TR, Parker AL, Willumsen N, Bülow Sand JM, Jenkins G, Hansen HH, Oldenburger A, Geillinger-Kaestle KE, Larsen AT, Black D, Genovese F, Eckersley A, Heinz A, Nyström A, Nielsen SH, Bennink L, Johannsson L, Bay-Jensen AC, Orange DE, Friedman S, Røpke M, Fiore V, Schuppan D, Rieder F, Simona B, Borthwick L, Skarsfeldt M, Wennbo H, Thakker P, Stoffel R, Clarke GW, Kalluri R, Ruane D, Zannad F, Mortensen JH, Sinkeviciute D, Sundberg F, Coseno M, Thudium C, Croft AP, Khanna D, Cooreman M, Broermann A, Leeming DJ, Mobasheri A, Ricard-Blum S
Journal of Clinical Medicine (2025) [doi: 10.3390/jcm14061856]
PubMed | HTML (Open Access) | PDF
94. Photochemistry as a tool for dynamic modulation of hydrogel mechanics
Major GS, Joukhdar H, Choi YS, Rnjak-Kovacina J, Wise SG, Ju LJ, Cox TR, Xu C, Yeo GC, Young JL, Lim KS
Cell Reports Physical Sciences (2025) [doi: 10.1016/j.xcrp.2024.102366]
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2024
93. Sericin improves alginate-gelatin hydrogels’ mechanical properties, porosity, durability, and viability of fibroblasts in cardiac spheroids
Tarsitano M, Ming CLC, Idais D, Mahmodi H, Wyllie K, Isella B, Cox TR, Kabakova I, Paolino D, Gentile C
International Journal of Bioprinting (2024) [doi: 10.36922/ijb.5678]
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92. Chlorella-enriched hydrogels protect against myocardial damage and reactive oxygen species production in an in vitro ischemia/reperfusion model using cardiac spheroids
Tarsitano M, Ming CLC, Bennar L, Mahmodi H, Wyllie K, Idais D, Al Shamery W, Paolino D, Cox TR, Kabakova I, Ralph P, Gentile C
Biofabrication (2024) [doi: 10.1088/1758-5090/ad8266]
PubMed | HTML (Open Access) | PDF
91.Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice
Hjorth M, Egan CL, Telles GD, Pal M, Gallego-Ortega D, Fuller OK, McLennan ED, Gillis RD, Oh TG, Muscat GEO, Tegegne S, Mah MSM, Skhinas J, Estevez E, Adams TE, McKay MJ, Molloy M, Watt KI, Qian H, Gregorevic P, Cox TR, Hojman P, Midtgaard J, Christensen JF, Friedrichsen M, Iozzo RV, Sloan EK, Drew BG, Wojtaszewski JFP, Whitham M, Febbraio M
Journal of Sport & Health Science (2024) [doi: 10.1016/j.jshs.2024.100991]
PubMed | HTML (Open Access) | PDF
90. Droplet-based microfluidics for engineering shape-controlled hydrogels with stiffness gradient
Soliman BG, Chin IL, Li Y, Ishii M, Ho MH, Khanh DV, Cox TR, Wang PY, Lindberg GCJ, Zhang YS, Woodfield TBF, Choi YS, Lim SH
Biofabrication (2024) [doi: 10.1088/1758-5090/ad6d8e]
PubMed | HTML (Open Access) | PDF
89. Type XII collagen is elevated in serum from patients with solid tumors: a non-invasive biomarker of activated fibroblasts
Crespo-Bravo M, Hettich A, Thorlacius-Ussing J, Cox TR, Karsdal MA, Willumsen N
Clinical & Experimental Medicine (2024) [doi: 10.1007/s10238-024-01431-y]
PubMed | HTML (Open Access) | PDF
88. Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response
Pereira BA, Ritchie S, Chambers CR, Gordon KA, Magenau A, Murphy KJ, Nobis M, Tyma VM, Liew YF, Lucas MC, Naeini MM, Barkauskas DS, Chacon-Fajardo D, Howell AE, Parker AL, Warren SC, Reed DA, Lee V, Metcalf XL, Lee YK, O’Regan LP, Zhu J, Trpceski M, Fontaine ARM, Stoehr J, Rouet R, Lin X, Chitty JL, Porazinski S, Wu SZ, Filipe EC, Cadell AL, Holliday H, Yang J, Papanicolaou M, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Vennin C, Yin J, Dew AB, McMillan PJ, Goldstein LD, Deveson IW, Croucher DR, Samuel MS, Sim HW, Batten M, Chantrill L, Grimmond SM, Gill AJ, Samra J, Evans TRJ, Sasaki T, Phan TG, Swarbrick A, Sansom OJ, Morton JP, Australian Pancreatic Cancer Matrix Atlas (APMA), Australian Pancreatic Cancer Genome Initiative (APGI), Pajic M, Parker BL, Herrmann D, Cox TR#, Timpson P#
Science Advances (2024) [doi: 10.1126/sciadv.adl1197]
PubMed | HTML (Open Access) | PDF
87. Why do patients with cancer die?
Boire A, Burke K, Cox TR#, Guise T, Jamal-Hanjani M, Janowitz T, Kaplan R, Lee R, Swanton C, Vander Heiden MG, Sahai E#
Nature Reviews Cancer (2024) [doi: 10.1038/s41568-024-00708-4]
PubMed | HTML | PDF (Readcube)
86. The importance of 3D fibre architecture in cancer and implications for biomaterial design
Ashworth JC# & Cox TR#
Nature Reviews Cancer (2024) [doi: 10.1038/s41568-024-00704-8]
PubMed | HTML | PDF (Readcube)
85. Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks
Vettori L, Tran HA, Sarmast HMS, Filipe EC, Wyllie K, Ming CLC, Cox TR, Tipper J, Kabakova I, Rjnak-Kovacina J, Gentile C
Biofabrication (2024) [doi: 10.1088/1758-5090/ad4f1b]
PubMed | HTML (Open Access) | PDF
84. Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
Filipe EC#, Velayuthar S, Philp A, Nobis M, Latham SL, Parker AL, Murphy KJ, Wyllie K, Major GS, Contreras O, Mok ETY, Enriquez RF, McGowan S, Feher K, Quek LE, Hancock SE, Yam M, Tran E, Setargew YFI, Skhinas J, Chitty JL, Phimmachanh M, Han JZR, Cadell AL, Papanicolaou M, Mahmodi H, Kiedik B, Junankar S, Ross SE, Lam N, Coulson R, Yang J, Zaratzian A, Da Silva AM, Tayao M, Chin IL, Cazet A, Kansara M, Segara D, Parker A, Hoy AJ, Harvey RP, Bogdanovic O, Timpson P, Croucher DR, Lim E, Swarbrick A, Holst J, Turner N, Choi YS, Kabakova IV, Philp A, Cox TR#
Advanced Science (2024) [doi: 10.1002/advs.202307963]
PubMed | HTML (Open Access) | PDF
83. miRNAs in pancreatic cancer progression and metastasis
Mok ETY, Chitty JL#, Cox TR#
Clinical & Experimental Metastasis (2024) [doi: 10.1007/s10585-023-10256-0]
PubMed | HTML (Open Access) | PDF
2023
82. The role of peroxidasin in solid cancer progression
Wyllie K, Panagopoulos V#, Cox TR#
Biochemical Society Transactions (2023) [doi: 10.1042/BST20230018]
PubMed | HTML (Open Access) | PDF
81. The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer-associated fibroblast subtypes
Thorlacius-Ussing J, Jensen C, Nissen NI, Cox TR, Kalluri R, Karsdal M, Willumsen N
Journal of Pathology (2023) [doi: 10.1002/path.6207]
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80. A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
Chitty J, Yam, M, Perryman L, Parker AL, Skhinas JN, Setargew YFI, Mok ETY, Tran E, Grant RD, Latham SL, Pereira BA, Ritchie SC, Murphy KL, Trpceski M, Findlay AD, Melenec P, Filipe EC, Nadalini A, Velayuthar S, Major G, Wyllie K, Papanicolaou M, Ratnaseelan S, Phillips PA, Sharbeen G, Youkhana J, Russo A, Blackwell A, Hastings JF, Lucas MC, Chambers CR, Reed DA, Stoehr J, Vennin C, Pidsley R, Zaratzian A, Da Silva AM, Tayao M, Charlton B, Herrmann D, Nobis M, Clark SJ, Biankin AV, Johns AL, Croucher DR, Nagrial A, Gill AJ, Grimmond SG, The Australian Pancreatic Genome Initiative (APGI), The Australian Pancreatic Cancer Matrix Atlas (APMA), Pajic M, Timpson P, Jarolimek W#, Cox TR#
Nature Cancer (2023) [doi: 10.1038/s43018-023-00614-y]
PubMed | HTML (Open Access) | PDF
79. Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment
Widodo SS*, Dinevska M*, Cuzcano L, Papanicolaou M, Cox TR, Stylli SS, Mantamadiotis T
Advances in Cancer Biology & Metastasis (2023) [doi: 10.1016/j.adcanc.2023.100096]
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78. Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
Hastings JF*, Latham SL*, Kamali A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Pantarelli C, Cadell AL, O’Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR
Science Advances (2023) [doi: 10.1126/sciadv.abp8314]
PubMed | HTML (Open Access) | PDF
2022
77. Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma
Parker AL#, Bowman E, Zingone A, Ryan BM, Cooper WA, Kohonen-Corish M, Harris CC, Cox TR#
Genome Medicine (2022) [doi: 10.1186/s13073-022-01127-6]
PubMed | HTML (Open Access)
76. Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
Jamaluddin MFB, Ghosh A, Ingle A, Mohammed R, Ali A, Bahrami M, Kaiko G, Gibb Z, Filipe EC, Cox TR, Boulton A, O’Sullivan R, Ius Y, Karakoti A, Vinu A, Naha P, Jaaback K, Bansal V, Tanwar P
Proc. Natl Acad. Sci. USA (PNAS) (2022) [doi: 10.1073/pnas.2208040119]
PubMed | HTML
75. Dynamic dentin: A quantitative microscopic assessment of age and spatial changes to matrix architecture, peritubular dentin, and collagens types I and III
Weerakoon AT, Condon N, Cox TR, Sexton C, Cooper C, Meyers IA, Thompson D, Ford PJ, Roy S, Symons AL
Journal of Structural Biology (2022) [doi: 10.1016/j.jsb.2022.107899]
PubMed | HTML
74. Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
Papanicolaou M*, Parker AL*, Yam M, Filipe EC, Wu SZ, Chitty JL, Wyllie K, Tran E, Mok E, Nadalini A, Skhinas JN, Lucas MC, Herrmann D, Nobis M, Pereira BA, Law AMK, Castillo L, Murphy KJ, Zaratzian A, Hastings JF, Croucher DR, Lim E, Oliver BG, Valdes Mora F, Parker BL, Gallego-Ortega D, Swarbrick A, O’Toole S, Timpson P#, Cox TR#
Nature Communications (2022) [doi: 10.1038/s41467-022-32255-7]
PubMed | HTML | PDF
73. ALTEN: A high-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo
Law AMK, Chen J, Colio-Sanguino Y, Rodriguez de la Fuente L, Fang G, Grimes SM, Lu H, Huang RJ, Boyle ST, Venhuizen J, Castillo L, Tavakoli J, Skhinas JN, Millar EKA, Beretov J, Rossello FJ, Tipper JL, Cox TR, Martelotto L, Jin D, Valdes-Mora F, Ji HP, Gallego-Ortega D
Advanced Science (2022) [doi: 10.1002/advs.202103332]
PubMed | HTML | PDF
2021
72. Micromechanical characterisation of 3D bioprinted neural cell models using Brillouin microspectroscopy
Alsadat Rad M, Mahmodi H, Filipe EC, Cox TR, Kabakova I, Tipper JL
Bioprinting (2021) [doi: 10.1016/j.bprint.2021.e00179]
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71. Pirfenidone Reduces Epithelial–Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts
Aboulkheyr Es H, Cox TR, Sarafraz-Yazdi E, Thiery JP, Warkiani ME
Cancers (2021) [doi: 10.3390/cancers13205118]
PubMed | HTML
70. Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XE, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Australian Pancreatic Genome Initiative (APGI), Australian Pancreatic Cancer Matrix Atlas (APMA), Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz J, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic, M, Herrmann D, Timpson P
Science Advances (2021) [doi: 10.1126/sciadv.abh0363]
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69. Towards engineering heart tissues from bioprinted cardiac spheroids
Polonchuk L, Surija L, Lee MH, Sharma P, Ming CLC, Richter F, Ben-Sefer E, Alsadat Rad M, Sarmast HMS, Al Shamery W, Tran HA, Vettori L, Haeusermann F, Filipe EC, Rnjak-Kovacina J, Cox TR, Tipper J, Kabakova I, Gentile C
Biofabrication (2021) [doi: 10.1088/1758-5090/ac14ca]
PubMed | HTML
68. Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP
Guo G*, Papanicolaou M*, Demarais NJ, Wang Z, Schey KL, Timpson P, Cox TR#, Grey AC#
Nature Communications (2021) [doi: 10.1038/s41467-021-23461-w]
PubMed | HTML | PDF
67. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition
Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, Holst J , Boyer C, Erkan M, Goldstein D, Timpson P, Cox TR, Pereira BA, Chitty JL, Fey SK, Najumudeen AK, Campbell AD, Sansom OJ, Ignacio RMC, Naim S, Liu J, Russia N, Lee J, Chou A, Johns A, Gill AJ, Gonzales-Aloy E, Gebski V, Guan YF, Pajic M, Turner N, Apte MV, Davis TP, Morton JP, Haghighi KS, Kasparian J, McLean BJ, Setargew YFI, Australian Pancreatic Cancer Genome Initiative (APGI), Phillips PA
Cancer Research (2021) [doi: 10.1158/0008-5472.CAN-20-2496]
PubMed | HTML | PDF
66. Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype
Valdés-Mora F, Salomon R, Gloss BS, Law AMK, Venhuizen J, Castillo L, Murphy KJ, Magenau A, Papanicolaou M, Rodriguez de la Fuente L, Roden DL, Colino-Sanguino Y, Kikhtyak Z, Farbehi N, Conway JRW, Sikta N, Oakes SR, Cox TR, O’Donoghue SI, Timpson P, Ormandy CJ, Gallego-Ortega D
Cell Reports (2021) [doi: 10.1016/j.celrep.2021.108945 ]
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65. The Matrix in Cancer
Cox TR#
Nature Reviews Cancer (2021) [doi: 10.1038/s41568-020-00329-7]
PubMed | HTML | PDF (read-only)
64. Inhibitor of Differentiation4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB
Holliday H, Roden D, Junankar S, Wu SZ, Baker LA, Krisp C, Chan CL, McFarland A, Skhinas JN, Cox TR, Pal B, Huntington ND, Ormandy CJ, Carroll JS, Visvader J, Molloy MP and Swarbrick A
iScience (2021) [doi: 10.1016/j.isci.2021.102072]
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63. Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours
Setargew YFI*, Wyllie K*, Grant RD, Chitty JL# and Cox TR#
Cancers (2021) [doi: 10.3390/cancers13030491]
PubMed | HTML (Open Access) |PDF
2020
62. The Role of the ECM in Lung Cancer Dormancy and Outgrowth
Parker AL*# and Cox TR*#
Frontiers in Oncology (2020) [doi: 10.3389/fonc.2020.01766]
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61. Stromal cell diversity associated with immune evasion in human triple-negative breast cancer
Wu SZ, Roden DL, Wang C, Holliday H, Harvey K, Cazet AS, Murphy KJ, Pereira B, Al-Eryani G, Bartonicek N, Hou R, Torpy JR, Junankar S, Chan CL, Lam CE, Hui MN, Gluch L, Beith J, Parker A, Robbins E, Segara S, Mak C, Cooper C, Warrier S, Forrest A, Powell J, O’Toole S, Cox TR, Timpson P, Lim E, Lui XS, Swarbrick A
EMBO (2020) [doi: 10.15252/embj.2019104063]
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60. Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo
Michael P, Lam YT, Filipe EC, Tan RP, Chan AHP, Lee BSL, Feng N, Hung J, Cox TR, Santos M, Wise SG
Scientific Reports (2020) [doi: 10.1038/s41598-020-69591-x]
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59. Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan
Elgundi Z, Papanicolaou M, Major G, Cox TR, Melrose J, Whitelock JM, Farrugia BL
Frontiers in Oncology (2020) [doi: 10.3389/fonc.2019.01482]
PubMed | HTML (Open Access) | PDF
2019
58. Targeting the lysyl oxidases in tumour desmoplasia
Chitty JL, Setargew YFI, Cox TR#
Biochemical Society Transactions (2019) [doi: 10.1042/BST20190098]
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57. CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer
Pereira BA*, Vennin C*, Papanicolaou M, Chambers CR, Herrmann D, Morton JP, Cox TR#, Timpson P#
Trends in Cancer (2019) [doi: 10.1016/j.trecan.2019.09.010]
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56. CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, Australian Pancreatic cancer Genome Initiative (APGI), Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR#, Timpson P#
Nature Communications (2019) [doi: 10.1038/s41467-019-10968-6]
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55. The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development
Chitty JL, Skhinas JN, Filipe EC, Wang, S, Rodriguez Cupello C, Grant RD, Yam M, Papanicoloau M, Major G, Zaratzian A, Da Silva AM, Tayao M, Vennin C, Timpson P, Madsen CD#, Cox TR#
Cancer Reports (2019) [doi: 10.1002/cnr2.1209]
PubMed | HTML (Open Access) | PDF
54. The importance of developing therapies targeting the biological spectrum of metastatic disease.
Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA
Clinical & Experimental Metastasis (2019) [doi: 10.1007/s10585-019-09972-3]
PubMed | HTML
53. LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity
Zeltz C*, Pasko E*, Cox TR, Navab R, Tsao MS
Cancers (2019) [doi: 10.3390/cancers11050705]
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52. Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment.
Nguyen EV*, Pereira BA*, Lawrence MG, Ma X, Rebello RJ, Chan H, Niranjan B, Wu Y, Ellem S, Guan X, Wu J, Skhinas JN, Cox TR, Risbridger GP, Taylor RA, Lister NL, Daly R.
Molecular & Cellular Proteomics (2019) [doi: 10.1074/mcp.RA119.001496]
PubMed | HTML
51. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Kennedy SP*, Han JZR*, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O’Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR
Breast Cancer Research (2019) [doi: 10.1186/s13058-019-1127-y]
PubMed | HTML
50. The extracellular matrix as a key regulator of intracellular signalling networks
Hastings JF*, Skhinas JN*, Fey D, Croucher DR#, Cox TR#
British Journal of Pharmacology (2019) [doi: 10.1111/bph.14195]
PubMed | HTML | PDF
2018
49. Cancer cell ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Wullkopf L, West AV, Leijnse N, Cox TR, Madsen CD, Oddershede LB, Erler JT
Molecular Biology of the Cell (2018) [doi: 10.1091/mbc.E18-05-0319]
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48. Recent advances in understanding the complexities of metastasis
Chitty JL*, Filipe EC*, Lucas MC, Herrmann D, Cox TR#, Timpson P#
F1000Research (2018) [doi: 10.12688/f1000research.15064.1]
PubMed | HTML | PDF | Download Fig. 1 (Hi-Res)
47. Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Cazet AS*, Hui MN*, Elsworth BL, Wu SZ, Roden D, Chan CL, Skhinas JN, Collot R, Yang J, Harvey K, Johan MZ, Cooper C, Nair R, Herrmann D, McFarland A, Deng N, Ruiz-Borrego M, Rojo F, Trigo JM, Bezares S, Caballero R, Lim E, Timpson P, O’Toole S, Watkins ND,
Cox TR, Samuel MS, Martín M, Swarbrick A
Nature Communications (2018) [doi: 10.1038/s41467-018-05220-6]
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46. Tumor endothelial marker 8 promotes cancer progression and metastasis.
Høye AM*, Tolstrup SD*, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT
Oncotarget (2018) [doi: 10.18632/oncotarget.25734]
PubMed | HTML | PDF
45. Removing physiological motion from intravital and clinical functional imaging data
Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JRW, Melenec P, Cox TR, Wang Y, Morton JP, Welch, HCE, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P
eLife (2018) [doi: 10.7554/eLife.35800]
PubMed | HTML | PDF | Download Galene
44. Charting the unexplored extracellular matrix in cancer
Filipe EC*, Chitty JL*, Cox TR#
International Journal of Experimental Pathology (2018) [doi: 10.1111/iep.12269]
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43. Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse
Nobis M, Herrmann D, Warren SC, Cox TR, Anderson KI, Timpson P
Small GTPases (2018) [doi: 10.1080/21541248.2018.1438024]
PubMed | HTML| Request a Copy
42. Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P
Gastroenterology (2018) [doi: 10.1053/j.gastro.2017.11.280]
PubMed | HTML | Request a Copy
41. Proteomic Characterisation of Caenorhabditis elegans Larval Development
Xia T*, Horton ER*, Salcini AE, Pocock R, Cox TR#, Erler JT#
Proteomics (2018) [doi: 10.1002/pmic.201700238]
PubMed | HTML
40. Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Cox TR#, Erler JT and Rumney RMH#
Calcified Tissue International (2018) [doi: 10.1007/s00223-017-0352-6]
PubMed | HTML
39. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example
Fingleton B, Lange K, Caldwell B, Bankaitis KV, Board of the Metastasis Research Society (Kang Y, Yu D, Aguirre-Ghiso J, Cox TR, Erler JT, Gelman IH, Hurst DR, Kato Y, Lynch CC, Price JT, Samant RS, Sleeman J, Stein U, Zijlstra A)
Clinical & Experimental Metastasis (2018) [doi: 10.1007/s10585-017-9872-8]
PubMed | HTML
38. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou A, Froio D, Nagrial AN, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ, Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M
Gut (2018) [doi: 10.1136/gutjnl-2017-315144]
PubMed | HTML
37. The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.
Skhinas JN and Cox TR#
Cell Adhesion & Migration (2018) [doi: 10.1080/19336918.2017.1405208]
PubMed | HTML
2017
36. Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR#, Timpson P#
Scientific Reports (2017) [doi: 10.1038/s41598-017-17177-5]
PubMed | HTML
35. Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy
Vennin C, Cox TR, Pajic M, Timpson P
Oncotarget (2017) [doi: 10.18632/oncotarget.21468]
PubMed | HTML
34. Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Koplev S*, Longden J*, Ferkinghoff-Borg J*, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Reports (2017) [doi: 10.1016/j.celrep.2017.08.095]
PubMed | HTML
33. ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Mayorca-Guiliani AE*, Madsen CD*, Cox TR*, Horton ER, Venning FA, Erler JT
Nature Medicine (2017) [doi: 10.1038/nm.4352]
PubMed | HTML | PDF
32. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Vennin C*, Chin VT*, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec A, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans TRJ, Anderson KI, Gray ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.
Science Translational Medicine (2017) [doi: 10.1126/scitranslmed.aai8504]
PubMed | HTML
31. Relative Stiffness Measurements of Tumour Tissues by Shear Rheology
Madsen CD# and Cox TR#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2265]
HTML
30. Pre-metastatic niches: organ-specific homes for metastases
Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissel MJ, Cox TR, Giaccia A, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.
Nature Reviews Cancer (2017) [doi: 10.1038/nrc.2017.6]
PubMed | HTML
29. Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang J, Lucas M, Leonte L, Garcia-Montolio M, Babloo Singh L, Findlay A, Deodhar M, Foot J, Jarolimek W, Timpson P, Erler JT#, Cox TR#
Oncotarget (2017) [doi: 10.18632/oncotarget.15257]
PubMed | HTML
28. Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight
Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS ONE (2017) [doi: 10.1371/journal.pone.0169664]
PubMed | HTML
27. Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro
Cox TR# and Madsen CD#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2101]
HTML
26. Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Scientific Reports (2017) [doi: 10.1038/s41598-017-00144-5]
PubMed | HTML
2016
25. The Role of Lysyl Oxidase, the Extracellular Matrix and the Pre-Metastatic Niche in Bone Metastasis
Gartland A, Erler JT and Cox TR
Journal of Bone Oncology (2016) [doi: 10.1016/j.jbo.2016.04.001]
PubMed | HTML
24. Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Cox TR# and Erler JT#
Trends In Cancer (2016) [doi: 10.1016/j.trecan.2016.05.004]
HTML
23. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients
Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget (2016) [doi: 10.18632/oncotarget.9623]
PubMed | HTML (Open Access)
22. Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis
Cox TR#, Gartland A, Erler JT
Cancer Research (2016) [doi: 10.1158/0008-5472.CAN-15-2306]
PubMed | HTML | PDF
2015
21. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism
Cox TR*#, Schoof EM*, Gartland A, Erler JT, Linding R#
Data In Brief (2015) [doi: 10.1016/j.dib.2015.09.039]
PubMed | HTML | PDF (Open Access)
20. Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer
Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell (2015) [doi: 10.1016/j.cell.2015.08.056]
PubMed | HTML | PDF (Open Access)
19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.
EMBO Reports (2015) [doi: 10.15252/embr.201540107]
PubMed | HTML | PDF (Open Access)
18. AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C, Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
The Journal of Pathology (2015) [doi: 10.1002/path.4485]
PubMed | HTML | PDF
2014
17. Molecular pathways: connecting fibrosis and solid tumor metastasis
Cox TR# and Erler JT#
Clinical Cancer Research (2014) [doi: 10.1158/1078-0432.CCR-13-1059]
PubMed | HTML | PDF
16. Lysyl oxidase in colorectal cancer
Cox TR and Erler JT
American Journal of Physiology – Gastrointestinal and Liver Physiology (2014) [doi: ]
PubMed | HTML | PDF
15. Fibrosis, cancer and the premetastatic niche
Cox TR# and Erler JT#
Breast Cancer Management (2014) doi: 10.2217/bmt.14.36
HTML | PDF
2013
14. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research (2013) [doi: 10.1186/bcr3461]
PubMed | HTML | PDF
13. The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis
Cox TR and Erler JT
Journal of Carcinogenesis & Mutagenesis (2013) [doi: 10.4172/2157-2518.S13-001]
HTML | PDF
12. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research (2013) [doi: ]
PubMed | HTML | PDF
11. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds A, Cox TR, Erler JT
Cancer Research (2013) [doi: ]
PubMed | HTML | PDF
10. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
Baker AM, Lang G, Bird D, Cox TR#, Erler JT#
Oncogene (2013) [doi: 10.1038/onc.2012.202]
PubMed | HTML | PDF
2012
9. Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future
Cox TR and Erler JT
Tumor Microenvironment and Therapy (2012) [doi: 10.2478/tumor-2012-0002]
HTML | PDF
8. The rationale for targeting the LOX family in cancer
Barker HE*, Cox TR* and Erler JT
Nature Reviews Cancer (2012) [doi: 10.1038/nrc3319]
PubMed | HTML | PDF
7. The pre-metastatic niche: is metastasis random?
Cox TR, Gartland A and Erler JT
BoneKEy Reports (2012) [doi: 10.1038/bonekey.2012.80]
PubMed | HTML | PDF
2011
6. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox TR and Erler JT
Disease Models and Mechanisms (2011) []
PubMed | HTML | PDF
5. The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT
Journal of the National Cancer Institute (2011) [doi: 10.1093/jnci/djq569]
PubMed | HTML | PDF
4. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Research (2011) [doi: ]
PubMed | HTML | PDF
2010
3. Tissue section AFM: In situ ultrastructural imaging of native biomolecules
Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biology (2010) [doi: 10.1016/j.matbio.2010.01.008]
PubMed | HTML | PDF
2009
2. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Erler JT*, Bennewith KL*, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ
Cancer Cell (2009) [doi: 10.1016/j.ccr.2008.11.012]
PubMed | HTML | PDF
2008
1. Lamin A/C is a risk biomarker in colorectal cancer
Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ
PLOSOne (2008) [doi: 10.1371/journal.pone.0002988]
PubMed | HTML | PDF
6. The role of collagens and fibroblasts in cancer
Nissen NI, Karsdal MA, Cox TR, Willumsen N
In Biochemistry of Collagens, Laminins and Elastin (Third Edition)
Karsdal M (Ed.)
Leeming DJ, Henriksen K, Bay-Jensen AC, Nielsen SG, Bager CL, Schuppan D, Ricard-Blum S, Cox TR, White ES, Miner J, Heinz A (Co-Eds.)
Academic Press (2023)
ISBN 978-0-443-15617-5
HTML
5. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
Ramchandani D, El Rayes TP, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment (Second Edition)
Akslen LA, Watnick RS (Eds.)
Springer International Publishing (2022)
ISBN 978-3-030-98949-1
doi: 10.1007/978-3-030-98950-7
HTML
4. In Vitro 3D Models of Tunable Stiffness
Filipe EC*, Parker AL*, Cadell AL, Major G, Croucher DR, Cox TR#
In Metastasis: Methods in Molecular Biology
Stein U (Ed.)
Humana Press, Springer (2021)
ISBN 978-1-0716-1350-4
doi: 10.1007/978-1-0716-1350-4_3
HTML
3. The Extracellular Matrix (ECM)
Papanicolaou M and Cox TR#
In Encyclopedia of Molecular Pharmacology
Offermanns S, Rosenthal W (Eds.)
Springer, Cham (2021)
ISBN 978-3-030-21573-6
doi: 10.1007/978-3-030-57401-7_5691
HTML
2. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
El Rayes T, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment (First Edition)
Akslen LA, Watnick RS (Eds.)
Springer International Publishing (2017)
ISBN 978-3-319-39147-2
doi: 10.1007/978-3-319-39147-2_13
HTML
1. Remodelling of the Extracellular Matrix: Implications for Cancer
Cox TR and Erler JT
In Cell and Molecular Biology of Breast Cancer
Schatten H (Ed.)
Humana Press, Springer (2013)
ISBN 978-1-62703-633-7
doi: 10.1007/978-1-62703-634-4_4
HTML
A bioinformatics engine for automated annotation and visualisation of high-resolution spatial proteomics mass spectrometry imaging data
Garvan Institute of Medical Research (2021)
Inventors: Guo G, Papanicoloau M, Cox TR, Grey AC
PCT/AU2021/030363
ALTEN (Alginate-based Tissue Encapsulation): a method for encapsulating animal tissue in an alginate-based hydrogel for drug-screening in the context of personalised cancer therapies
Garvan Institute of Medical Research (2020)
Inventors: Law A, Skhinas JN, Cox TR, Gallego-Ortega D
PCT/AU2020/050129
Methods for determining a prognosis of colorectal cancer
University of Durham (2007)
Inventors: Cox TR, De Bruin A, Hutchison CJ, Przyborski S, Van Engeland M, Wilson R
WO2007148095 A8
